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Oxidative stress is controlled very tightly in the thyroid gland via the synthesis of glutathione peroxidase, which can safely inactivate sources of oxidative stress, such as hydrogen peroxide and free radicals

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Further, OPG gene polymorphisms and increased OPG expression levels may contribute to IVDD development (81)

However, for mass spectrometric immunoassays (MSIA), IGF-1 is detected by the measurement of its intrinsic molecular mass and, therefore, alternate forms of IGF-1 that differ in mass can be readily differentiated